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Gary Boehm

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Professor Direct: 817.257.6082
Ph.D. University of Connecticut, 1996

Research Interests

Neural-immune interactions, Alzheimer’s disease, proinflammatory cytokines, evolutionary psychology, learning and memory

Research in our lab focuses primarily on ways in which the brain and immune system interact with one another, both in health and in sickness/disease. More specifically, our lab focuses on how proinflammatory cytokines, triggered by immune events, stress, or poor health, may harm aspects of learning and memory, or adversely affect other cognitive processes. Whether exacerbating Alzheimer’s-related neuropathology, or altering varied cognitive processes, we seek to understand and combat adverse effects of inflammation.

Selected Publications:

Gassen, J., Prokosch, M. L., Eimerbrink, M. J., Proffitt Leyva, R. P., White, J. D., Peterman, J. L., Burgess, A., Cheek, D. J., Kreutzer, A., Nicolas, S. C., Boehm, G. W., and Hill, S. E. (2019). Inflammation predicts decision-making characterized by impulsivity, present focus, and an inability to delay gratification. Scientific Reports, 9: 4928. doi: 10.1038/s41598-019-41437-1.

Eimerbrink, M. J., Pendry, R. J., Hodges, S. M., Wiles, J. D., Peterman, J. L., White, J. D., Hayes H. B., Chumley, M. J., and Boehm, G. W. (2019). The α5-GABAAR inverse agonist MRK-016 upregulates hippocampal BDNF expression and prevents cognitive deficits in LPS-treated mice, despite elevations in hippocampal Aβ.  Behavioural Brain Research, 359: 871-877.

Gassen, J., Prokosch, M. L., Makhanova, A., Eimerbrink, M. J., White, J. D., Profitt Leyva, R. P., Peterman, J. L., Nicolas, S. C., Reynolds, T. A., Maner, J. K., McNulty, J. K., Eckel, L. A., Nikonova, L., Brinkworth, J. F., Phillips, M. D., Mitchell, J. B., Boehm, G. W., Hill, S. E. (2018). Behavioral immune system activity predicts downregulation of chronic basal inflammation. PLoS One, 13: e0203961, doi: 10.1371/journal.pone.0202961

White, J. D., Eimerbrink, M. J., Hayes, H. B., Hardy, A., Van Enkevort, E. A., Peterman, J. L., Chumley, M. J., and Boehm, G. W. (2016). Hippocampal Ab expression, but not phosphorylated tau, predicts cognitive deficits following repeated peripheral poly I:C administration. Behavioural Brain Research, 313: 219–225. Doi: 10.1016/j.bbr.2016.07.032.

Eimerbrink, M. J., White, J. D., Pendry, R. J., Hodges, S. L., Sadler, L. N., Wiles, J. D., Weintraub, M. K., Chumley, M. J., Boehm, G. W. (2015). Administration of the inverse benzodiazepine agonist MRK-016 rescues acquisition and memory consolidation following peripheral administration of bacterial endotoxin. Behavioural Brain Research, 288: 50–53.

Weintraub, M. K., Bisson, C. M., Nouri, J. M., Vinson, B. T., Kranjac, D., Eimberbrink, M. J., Boehm, G. W., Chumley, M. J. (2013). Imatinib methanesulfonate reduces hippocampal amyloid-beta and rescues memory disrupted by repeated endotoxin exposure. Brain, Behavior, and Immunity33: 24–28.

Kranjac, D., Koster, K. M., Kahn, M. S., Eimerbrink, M. J., Womble, B. M., Cooper, B. G., Chumley, M. J., Boehm, G. W. (2013). Peripheral administration of D-cycloserine rescues memory consolidation following bacterial endotoxin exposure. Behavioural Brain Research, 243: 38–43.

Kranjac, D., McLinden, K. A., Deodati, L. E., Papini, M. R., Chumley, M. J., Boehm, G. W. (2012). Peripheral bacterial endotoxin administration triggers both memory consolidation and reconsolidation deficits in mice. Brain, Behavior, and Immunity26:109–121.

Teaching Responsibilities

Teaching Responsibilities: Intro Neuroscience, Advanced Neuroscience,

Principles of Behavior, Human Neuropsychology, Functional Neuroanatomy

Service Responsibilities: Vivarium Director

Professional Affiliations: Society for Neuroscience (SfN), PsychoNeuroImmunology Research Society (PNIRS)