Neural-immune interactions, exercise, Alzheimer’s Disease.
Research in our lab focuses primarily on ways in which the brain and immune system interact with one another, both in health, and in sickness/disease. More specifically, our lab focuses on how proinflammatory cytokines triggered by peripheral immune events may harm aspects of learning and memory, and other cognitive processes. Moreover, we have begun exploring how peripheral immune events may also trigger amyloid-beta and Alzheimer’s-like pathology in the brain, and varied means of combatting these adverse effects.
Weintraub, M. K., Bisson, C. M., Nouri, J. M., Vinson, B. T., Kranjac, D., Eimberbrink, M. J., Boehm, G. W., Chumley, M. J. (2013). Imatinib methanesulfonate reduces hippocampal amyloid-beta and rescues memory disrupted by repeated endotoxin exposure. Brain, Behavior, and Immunity, 33: 24–28.
Kranjac, D., Koster, K. M., Kahn, M. S., Eimerbrink, M. J., Womble, B. M., Cooper, B. G., Chumley, M. J., Boehm, G. W. (2013). Peripheral administration of D-cycloserine rescues memory consolidation following bacterial endotoxin exposure. Behavioural Brain Research, 243: 38–43.
Kranjac, D., McLinden, K. A., Deodati, L. E., Papini, M. R., Chumley, M. J., Boehm, G. W. (2012). Peripheral bacterial endotoxin administration triggers both memory consolidation and reconsolidation deficits in mice. Brain, Behavior, and Immunity, 26:109–121.
Byler, S. L., Boehm, G. W., Karp, J.D., Kohman, R. A., Tarr, A. J., Schallert, T., and Barth, T. M. (2009). Systemic lipopolysaccharide plus MPTP as a model of dopamine loss and gait instability in C57BL/6J mice. Behavioural Brain Research, 198: 434–439.
Teaching Responsibilities: Intro Neuroscience, Advanced Neuroscience,
Principles of Behavior, Human Neuropsychology, Functional Neuroanatomy
Service Responsibilities: Vivarium Director
Professional Affiliations: Society for Neuroscience (SfN), PsychoNeuroImmunology Research Society (PNIRS)